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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Juglone, Sodium selenite
Phytochemical Name Juglone (PubChem CID: 3806 )
Anticancer drug Name Sodium selenite (PubChem CID: 24934 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 310
Ref_1
Pair Name Juglone, Sodium selenite
Disease Info [ICD-11: 2C10.Z] Pancreatic cancer Investigative
Biological Phenomena Inhibition-->Cell metastasis
Gene Regulation Down-regulation Expression ITGB3 hsa3690
Up-regulation Expression CDH1 hsa999
Up-regulation Expression ITGB3 hsa3690
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0186
Result The juglone-NaSe has the potential to be a promising agent especially to inhibit invasion and metastasis in pancreatic cancer treatment. However, more in depth studies are needed to more clearly demonstrate the effects of juglone-selenium.
03. Reference
No. Title Href
1 The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines. Afr Health Sci. 2022 Jun;22(2):334-342. doi: 10.4314/ahs.v22i2.37. Click
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